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I tried cagri + reta because reta doesn’t do enough in terms of appetite

Started by Member 22259 131 replies 11 people Last activity Jul 16, 2026

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Member 71388 17 postsfirst seen Mar 2026
Mar 27, 2026 #88
im switching to high dose reta though when my order arrives
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Member 71388 17 postsfirst seen Mar 2026
Mar 27, 2026 #89
i do not didnt really notice any change in my mood except for not being hungry at all AT ALL
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Member 29409 514 postsfirst seen Oct 2025
Mar 27, 2026 #92
Jonah, when you said about retas gip ratio, are you referring to the blood sugar effect?
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Member 80411 1,083 postsfirst seen Nov 2025
Mar 27, 2026 #98
Yeah, like, the glucagon amount was chosen based on reta's GIP affinity which is 9x stronger than Tirz's
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Member 80411 1,083 postsfirst seen Nov 2025
Mar 27, 2026 #99
Or was it sema? Either way, reta GIP stronk af
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Member 80411 1,083 postsfirst seen Nov 2025
Mar 27, 2026 #100
But its GLP1 binding is weaker, which is why appetite suppression isn't as strong
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